Measure subcellular structure changes with axial super resolution . This project aims to provide a facile approach to axial super-resolution, assisted by a metasurface. This scheme will provide a gene

Description

Measure subcellular structure changes with axial super resolution . This project aims to provide a facile approach to axial super-resolution, assisted by a metasurface. This scheme will provide a generalized strategy for quantitatively measuring sub-diffraction limit conformational changes in live cells, as demonstrated through the measurement of immune response in macrophages. With simultaneous control of surface morphology at the nanoscale, this project will generate new knowledge for the design of an optically responsive metasurface that is highly sensitive to distance and topography. Expected outcomes include a universal platform for the precise study of membrane conformation, mechanosensing, and cell migration, making substantial contributions to the progress of cell biological research. . Scheme: Discovery Early Career Researcher Award. Field: 4003 - Biomedical Engineering. Lead: Dr Yuyang Gu