Understanding nicotine metabolism during pregnancy in First Nations peoples. This project aims to be the world-first to investigate the ways Indigenous Australians metabolise nicotine over pregnancy.

Description

Understanding nicotine metabolism during pregnancy in First Nations peoples. This project aims to be the world-first to investigate the ways Indigenous Australians metabolise nicotine over pregnancy. Differences in nicotine metabolism are caused by genetic factors, yet data mainly comes from white women in the US & UK, and there is no scientific data on how Indigenous mothers metabolise nicotine. This project will utilise biochemical & genomic analysis to generate this new knowledge. Expected outcomes include highly accurate models for predicting nicotine levels over pregnancy & new theories linking Indigenous heritage with specific metabolism types. This would yield significant benefits through adding to the global knowledgebase, challenging generalisation of non-Indigenous data, & future impacts on health policy.. Scheme: Discovery Indigenous. Field: 4506 - Aboriginal and Torres Strait Islander Sciences. Lead: Dr Jared Miles