Identifying how cortical bone microstructure deteriorates with age. This project aims to define the disruptions responsible for the gradual weakening of the skeleton in ageing by integrating a range o

Description

Identifying how cortical bone microstructure deteriorates with age. This project aims to define the disruptions responsible for the gradual weakening of the skeleton in ageing by integrating a range of high-resolution imaging, biomechanical, and computational methods. The expected significance of this project includes a full definition and comparison of the cellular and subcellular organisation of bone from young and elderly individuals. Expected outcomes of this international project include the establishment of a new multidisciplinary research team, and the development of a new data-driven theoretical framework for understanding the nature and the causes of age-related bone fragility. Potential long-term benefits include new ways to treat age-related osteoporosis.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Natalie Sims