Engineering enzymes for controlled peptide modification. This project aims to (1) understand the mechanism and control the specificity of peptide crosslinking by engineered enzymes and (2) to exploit

Description

Engineering enzymes for controlled peptide modification. This project aims to (1) understand the mechanism and control the specificity of peptide crosslinking by engineered enzymes and (2) to exploit these enzymes as biocatalysts to produce complex bioactive peptides. This project intends to generate new knowledge on the biocatalytic synthesis of peptides using a highly interdisciplinary approach and essential tools that have been developed. The anticipated outcomes of this project are an enhanced understanding of how to the control the function of biocatalysts for peptide synthesis and to use these biocatalysts to synthesis complex bioactive natural products. This knowledge is vital for future efforts to develop biocatalytic methods for peptide production.. Scheme: Discovery Projects. Field: 3404 - Medicinal and Biomolecular Chemistry. Lead: Prof Max Cryle