Enhancing Antimicrobial Activity Using Synergistic Resistance Mitigation. This project aims to combat antibiotic resistance by developing synergistic compounds targeting the extracellular polymeric su

Description

Enhancing Antimicrobial Activity Using Synergistic Resistance Mitigation. This project aims to combat antibiotic resistance by developing synergistic compounds targeting the extracellular polymeric substance in biofilms. Utilizing Neolixir's NeoX-101 platform, compounds will be screened to identify combinations disrupting the extracellular polymeric matrix. New insights into nanoscale extracellular polymeric matrix interactions will be generated using metabolomics and high-resolution imaging. Outcomes include an extracellular polymeric matrix-targeting toolbox for potentiating antibiotics and a robust screening pipeline. Benefits include accelerating novel antibiotic resistance strategies and fostering polymer and nanoscale imaging innovation against biofilm infections. . Scheme: Linkage Projects. Field: 3403 - Macromolecular and Materials Chemistry. Lead: Prof Killugudi Swaminatha-Iyer