Unlocking sperm transcription via mechanical stimulation. This project aims to reveal how the shape and fluid properties of the mammalian female reproductive tract help sperm switch on previously hidd

Description

Unlocking sperm transcription via mechanical stimulation. This project aims to reveal how the shape and fluid properties of the mammalian female reproductive tract help sperm switch on previously hidden genetic instructions for fertilisation. Using specialised micron-sized fluidic devices to mimic these conditions, this project will uncover the biological steps that enable sperm to adapt, produce new proteins, and prepare for fertilisation. Expected outcomes include identifying proteins that support egg recognition and energy use, as well as gaining new insights into the molecular biology of sperm migration within the mammalian reproductive tract. This knowledge may lead to new understanding and better animal breeding methods.. Scheme: Discovery Projects. Field: 4012 - Fluid Mechanics and Thermal Engineering. Lead: A/Prof Reza Nosrati