Cellular recycling, a route to productivity in ageing. . How can we age but remain productive? This impacts on Australia’s ageing workforce and productive lifespans of livestock and plants in a

Description

Cellular recycling, a route to productivity in ageing. . How can we age but remain productive? This impacts on Australia’s ageing workforce and productive lifespans of livestock and plants in agriculture. Remarkably, ageing in all species is linked to autophagy, the cells ‘garbage disposal system’ that declines with age. This project investigates an innovative strategy to sustain the anti-ageing power of autophagy by stimulating production of an essential component, lysosomes. Outcomes include understanding how autophagy failure impacts on muscle function and mobility, major contributors to a productive life. Our in-depth mechanistic characterization of lysosome production will identify targets to mitigate ageing, providing opportunities for long term benefits across broad socioeconomic sectors. . Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Christina Mitchell