'Splitting' of dying cells by neighbouring phagocytes to aid cell clearance. This project aims to investigate how fragmentation of dying cells could aid their removal. More than 200 billions cells die

Description

'Splitting' of dying cells by neighbouring phagocytes to aid cell clearance. This project aims to investigate how fragmentation of dying cells could aid their removal. More than 200 billions cells die daily in the human body. It is critical that dying cells are rapidly cleared as their buildup can interfere with normal tissue functions. This project will use a suite of contemporary molecular/cell biological approaches to study a newly identified process that occurs during cell clearance. Expected outcomes include a paradigm-shift in understanding the process of cell death and clearance. This project is expected to generate fundamental new knowledge of the mechanisms by which dying cells are efficiently removed from tissues. This should provide significant benefits to the cell death and general cell biology fields.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Ivan Poon