Broad molecular characterisation of the vertebrate T cell complex. T cells play central roles in vertebrate immunity yet we lack molecular insight into how the T cell receptor complex triggers develop

Description

Broad molecular characterisation of the vertebrate T cell complex. T cells play central roles in vertebrate immunity yet we lack molecular insight into how the T cell receptor complex triggers development and cellular activation. This project aims to establish how a cell-surface protein complex on T cells, orchestrates their development and function. Expected outcomes include the generation of fundamental knowledge in immunology and membrane receptor biology. This proposal uses advanced microscopy, including advancement of cryo-electron microscopy and single-molecule light microscopy capabilities, this will enable advanced postgraduate student training. Other outcomes include influential publications, building expertise at Australian universities and establishing international collaborations.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Dr Benjamin Gully