Developing serial crystallography for room temperature structure & dynamics. This project aims to uncover the molecular structural dynamics of a bacterial enzyme responsible for protein folding in bac

Description

Developing serial crystallography for room temperature structure & dynamics. This project aims to uncover the molecular structural dynamics of a bacterial enzyme responsible for protein folding in bacteria. This project expects to generate new knowledge to guide the development of a new type of antibacterial to circumvent antibiotic resistance. Expected outcomes of this project include new experimental, computational and simulation tools for dynamic X-ray crystallography including new capabilities at the Australian Synchrotron for very small microcrystals of any biomolecule. This would provide a powerful new tool for the Australian structural biology community that should accelerate fundamental discoveries, including facilitating high-resolution structure determination of membrane proteins and drug development.. Scheme: ARC Future Fellowships. Field: 5110 - Synchrotrons and Accelerators. Lead: A/Prof Nadia Zatsepin