Recognition of acetylated lysine in control of protein and cell functions. Proteins are molecules that carry out most functions in organisms. They are naturally modified in cells to diversify their st

Description

Recognition of acetylated lysine in control of protein and cell functions. Proteins are molecules that carry out most functions in organisms. They are naturally modified in cells to diversify their structures and functions. This chemistry project aims to study one simple protein modification important in development, metabolism, inflammation and survival of organisms. Aims and outcomes include discovering how this modification is detected and removed, how it controls protein signalling in cells, and how chemicals can be designed to preserve it to maintain normal cell functions. Benefits include new knowledge on roles of proteins that detect this modification, new high-value chemicals designed to monitor or control them, new IP with commercial potential, and interdisciplinary training across chemistry and biology.. Scheme: Discovery Projects. Field: 3404 - Medicinal and Biomolecular Chemistry. Lead: Prof David Fairlie