Targeting an essential bridge between bacterial membranes. This project aims to reveal the function of a protein bridge that is found prevalently across bacteria. These bridges allow bacteria to trans

Description

Targeting an essential bridge between bacterial membranes. This project aims to reveal the function of a protein bridge that is found prevalently across bacteria. These bridges allow bacteria to transport molecules that they use to build membrane barriers which stop antibiotics from working, and appendages that they use to cause infections. The project expects to leverage networks between USA and Australia to structurally and biochemically observe how these bridges form and to invent innovative ways to block the formation and function of these bridges inside bacterial cells. The knowledge gained from this project will improve our understanding of how bacteria generate their cell surfaces and will likely benefit the future development of antibiotics that target these bridges to kill superbugs.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Dr Matthew Doyle