Advanced Glucated End Products in Immune Responses to Biomaterials. The overarching aim of this project is to discover the inflammatory role of Advanced Glycation End Products (AGEs) when adsorbed on

Description

Advanced Glucated End Products in Immune Responses to Biomaterials. The overarching aim of this project is to discover the inflammatory role of Advanced Glycation End Products (AGEs) when adsorbed on biomaterial surfaces and how rational surface engineering strategies can be used to modulate AGEs adsorption and improve inflammatory outcomes. Despite the well documented high complication rates of biomaterials used with sections of the population that have high blood levels of AGEs, at present, there is no knowledge of how AGEs may adsorb to biomaterial surfaces and promote inflammation. The outcomes of the project will create new fundamental knowledge that in the future can instruct the development of the next generation of biomaterials capable of controlling and directing the body’s inflammatory responses.. Scheme: Discovery Projects. Field: 4003 - Biomedical Engineering. Lead: Prof Krasimir Vasilev