Dynamic cell membrane remodelling regulates nutrient homeostasis. The cell surface provides a major barrier to all external molecules. We propose that eukaryotic cells have evolved a mechanism to tran

Description

Dynamic cell membrane remodelling regulates nutrient homeostasis. The cell surface provides a major barrier to all external molecules. We propose that eukaryotic cells have evolved a mechanism to transiently modify its protein composition by regulating the entry and/or exit of nutrient regulatory molecules to this barrier. This serves as a major mechanism by which cells make decisions about the choice of nutrient entry to maintain nutrient homeostasis in the face of a changing environment. In this proposal we will examine the full repertoire of the regulated cell surface nutrient regulatory mechanism by identifying regulated membrane proteins and the mechanism by which they undergo regulated transport to and from the cell surface. . Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof David James