Unlocking the Modified Proteome . We now know that proteins—the functional molecules that sustain life on our planet—are modified after production in the cell. While such modifications are strikingly

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Unlocking the Modified Proteome . We now know that proteins—the functional molecules that sustain life on our planet—are modified after production in the cell. While such modifications are strikingly common, their effect on protein function is largely unknown. This Fellowship aims to understand how and why nature modifies proteins to control biological activity. This vision will be underpinned by the development of innovative technologies, including automation, to produce modified proteins with exquisite precision and at scale. The project will uncover how modifications govern the activity of major protein classes, leading to transformative discoveries, and will provide significant benefits to Australian industry by transforming the way that therapeutic proteins are made.. Scheme: Australian Laureate Fellowships. Field: 3404 - Medicinal and Biomolecular Chemistry. Lead: Prof Richard Payne