On the origin of sex differences in gene regulation. Animals and humans have different traits depending on sex, such as manes present only in male lions. Many sex differences are not visible, such as

Description

On the origin of sex differences in gene regulation. Animals and humans have different traits depending on sex, such as manes present only in male lions. Many sex differences are not visible, such as in internal organs. All human organs display robust sex differences in molecular profiles, but the reason for these differences is not known. To determine whether sex differences arise due to differing sex chromosomes or differing hormones, the team developed a highly innovative rat model that can answer this. This project will elucidate which factors, sex chromosomes or hormones, drive sex differences in molecular regulators across multiple tissues, and during development, revolutionising the fundamental understanding of the origin of sex differences in mammals.. Scheme: Discovery Projects. Field: 3105 - Genetics. Lead: Prof Vincent Harley