Laser-Ionisable Tags for Broad Metabolic Imaging of Tissues and Cells. Mass spectrometry imaging can map molecular distributions within tissues for investigating region-specific metabolic processes. H

Description

Laser-Ionisable Tags for Broad Metabolic Imaging of Tissues and Cells. Mass spectrometry imaging can map molecular distributions within tissues for investigating region-specific metabolic processes. However, many important molecules are not detectable. This project aims to develop new chemical approaches and imaging technology for enhanced imaging of elusive metabolites. This will greatly improve the scientific impact of mass spectrometric imaging and create new insights into metabolite compositions, distributions and reprogramming in biological systems. Expected benefits are development of new technology and chemistry to unravel biochemical distributions and functions in heterogeneous tissues and cells that, in the future, could improve disease understanding and support biotechnology development.. Scheme: Discovery Projects. Field: 3401 - Analytical Chemistry. Lead: A/Prof Shane Ellis