Metal-based complexes and materials that challenge antimicrobial resistance. This research project focuses on the design, development, and application of new bismuth, gallium and indium compounds as a

Description

Metal-based complexes and materials that challenge antimicrobial resistance. This research project focuses on the design, development, and application of new bismuth, gallium and indium compounds as antimicrobial and anti-biofilm agents. These metals act as iron mimics in vivo and can exert antimicrobial activity while displaying low systemic toxicity in humans. The project aims to exploit this, and the inability of microbes to easily develop resistance towards metals, to combat bacteria for which modern drugs are rapidly becoming ineffective, as highlighted in the WHO list of critical and priority pathogens. The intended outcome is that efficacy will be driven through advances in synthetic and structural chemistry, discovering the mode of action, and creating anti-infective polymers and gels.. Scheme: Discovery Projects. Field: 3402 - Inorganic Chemistry. Lead: Prof Philip Andrews