Developing macrophage-based technologies for tissue regeneration. Different tissues show distinct regenerative capacities with an organism and across the phylogeny. What underlies this diversity in re

Description

Developing macrophage-based technologies for tissue regeneration. Different tissues show distinct regenerative capacities with an organism and across the phylogeny. What underlies this diversity in regenerative ability at cellular and molecular level is far from clear. Building on foundational discoveries in zebrafish, this study seeks to determine if this capacity could, in part, be explained through the properties of a component of the innate immune system, the macrophage, which preliminary data shows generates a transient pro-regenerative muscle stem cell niche in zebrafish. This study will determine if macrophage subtypes acts to coordinate regeneration in other tissues and systems and if a programable pro-regenerative cell can be made in vitro that stimulate regeneration in different settings.. Scheme: Linkage Projects. Field: 0601 - Biochemistry and Cell Biology. Lead: Prof Peter Currie