How does a cyclin dependent kinase regulate inflammatory responses to RNA? Cytosolic recognition of viral double-stranded RNA (dsRNA) is a highly conserved mechanism for sensing infection across organ

Description

How does a cyclin dependent kinase regulate inflammatory responses to RNA? Cytosolic recognition of viral double-stranded RNA (dsRNA) is a highly conserved mechanism for sensing infection across organims. How the immune system effectively distinguishes between viral RNA and cellular RNA remain enigmatic. We have recently performed a genome-wide CRISPR screen which identified novel regulators of cellular dsRNA. This project will use our unique models to address the substantial knowledge gap that exists in understanding the pathways that control immune responses to RNA how dysregulation of these pathways disrupts cellular homeostasis. We bring together expertise with a strong record for impactful outcomes in RNA biology, inflammation and proteomics to address this fundamental biology. . Scheme: Discovery Projects. Field: 3204 - Immunology. Lead: Dr Jacki Heraud-Farlow