A molecular investigation into the lipid antigen-presenting molecule, CD1a. This project aims to investigate the role of lipid antigen presentation in T cell mediated immunity, an area of research for

Description

A molecular investigation into the lipid antigen-presenting molecule, CD1a. This project aims to investigate the role of lipid antigen presentation in T cell mediated immunity, an area of research for which there is a very limited understanding. Using X-ray crystallography, biophysical measurements and cellular immunology, the project will provide structural data on how the lipid antigen-presenting molecule, CD1a, can bind an array of lipid classes, and how these CD1a-lipid complexes are subsequently recognised by the responding T cell repertoire. This project will generate new knowledge in the burgeoning field of lipid-mediated T cell immunity. This basic discovery project will lay the foundations for new therapies targeting the CD1a lipid display molecule.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Jamie Rossjohn