Illuminating the dark neutrophil glycoproteome. This project aims to shed light on the highly complex and dynamic sugar-coated surfaces of neutrophil white blood cells critical for the cell communicat

Description

Illuminating the dark neutrophil glycoproteome. This project aims to shed light on the highly complex and dynamic sugar-coated surfaces of neutrophil white blood cells critical for the cell communication and function of our innate immune system. The project expects to generate molecular-level insights into neutrophil biology by detailing the structure, formation, regulation, interactions and functions of these cell-surface sugars across the varied neutrophil life stages using systems glycobiology approaches. The project will map the extensive sugar remodelling on and in the neutrophil and reveal new sugar-mediated mechanisms governing key immune processes. This project will benefit the community by expanding our knowledge of fundamental processes underpinning our innate immune system.. Scheme: ARC Future Fellowships. Field: 0601 - Biochemistry and Cell Biology. Lead: Prof Morten Andersen