Unveiling Spatial and Temporal Regulation of Subcellular Protein Disorder. This project aims to develop innovative molecular tools to capture protein folding states within organelle proteomes in livin

Description

Unveiling Spatial and Temporal Regulation of Subcellular Protein Disorder. This project aims to develop innovative molecular tools to capture protein folding states within organelle proteomes in living cells for the first time. Protein localisation significantly influences folding, and mislocalisation can cause misfolding, contributing to disease. However, technical limitations have left a gap in understanding how localisation and folding are coordinated. These new tools will reveal how subcellular environments affect protein folding and how these processes change with ageing. This study will deliver innovative tools for research and commercialisation, and provide insights to inform future research on the diagnosis and treatment of age-related diseases, contributing to Australia’s scientific and economic growth.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Yuning Hong