Should I stay or should I go? How brain stem cells leave quiescence. Most adult stem cells in our brains are sleeping (quiescent). Quiescence helps ensure animals have a lifelong population of brain s

Description

Should I stay or should I go? How brain stem cells leave quiescence. Most adult stem cells in our brains are sleeping (quiescent). Quiescence helps ensure animals have a lifelong population of brain stem cells, which is crucial for the maintenance of brain circuitry. This project aims to investigate how this process is regulated at a molecular level. This project expects to define the molecular playbook controlling quiescence and explain why brain stem cells progress into deeper states of quiescence during aging by combining novel tissue culture and genetic models, where brain stem cells have disrupted quiescence, with innovative methods of reading gene expression. The benefits of these outcomes include the development of methods to control the quiescence of brain stem cells for bioengineering purposes.. Scheme: Discovery Early Career Researcher Award. Field: 3209 - Neurosciences. Lead: Dr Lachlan Harris