Understanding the role of sex in ageing muscle. This project aims to explore cause-and-effect relationships between molecular regulators and age- and sex-specific traits in skeletal muscle loss. Femal

Description

Understanding the role of sex in ageing muscle. This project aims to explore cause-and-effect relationships between molecular regulators and age- and sex-specific traits in skeletal muscle loss. Females live longer and are more susceptible to the functional and metabolic consequences of muscle ageing. Yet, our knowledge is overwhelmingly inferred from findings from male cohorts. Our results will establish the role of sex hormones and sex chromosomes on the origins, progression and consequences of age-related muscle loss, identifying transition points when risks to well-being and windows of opportunity are greatest. The project will produce essential knowledge allowing appropriate mitigation of the sex-specific consequences of muscle loss in males and females to promote healthy ageing.. Scheme: Discovery Projects. Field: 3105 - Genetics. Lead: Prof Severine Lamon