Roles of critical epithelial cell types in responses to metabolites. The mechanisms that enable the gut and lung epithelium to respond to stimuli and perform its function to maintain homeostasis are c

Description

Roles of critical epithelial cell types in responses to metabolites. The mechanisms that enable the gut and lung epithelium to respond to stimuli and perform its function to maintain homeostasis are critical, but ill-defined. We have developed novel tools and expertise that enable the elucidation of how specialised epithelial M cells and Tuft cells: 1. respond to bacterial metabolites and signal to immune cells to maintain homeostasis; 2. interact; and 3. how metabolite signals are altered in their absence in the gut and 4. lung. We will define the molecular crosstalk mechanisms that coordinate epithelial-immune function. This will unlock the potential to advance treatments and preventions (e.g. vaccines), enhancing our ability to combat major mucosal diseases threatening Australia's livestock and people.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Phil Hansbro