Symmetry making and breaking in neocortical development. Brain halves become wired during development following molecular and neural activity-dependent rules of symmetry. This project aims to unravel

Description

Symmetry making and breaking in neocortical development. Brain halves become wired during development following molecular and neural activity-dependent rules of symmetry. This project aims to unravel the mechanisms by which spatio-temporal symmetries between cortical hemispheres instruct the precise formation of functional connections. Using advanced methods in high-throughput gene expression analyses, live imaging of neural activity, behaviour, and connectivity mapping in a marsupial model of early brain patterning, this project aims to unravel new generative principles of mammalian brain circuit formation. Expected outcomes include innovative ways to manipulate brain wiring, and to functionally link mechanistic knowledge of complex trait formation across levels of biological organisation.. Scheme: Discovery Projects. Field: 3109 - Zoology. Lead: A/Prof Rodrigo Suarez