The molecular basis of rapid cellular replication in the malaria parasite. This research will reveal how malaria parasites perform extremely rapid replication of their DNA. Malaria is a major health b

Description

The molecular basis of rapid cellular replication in the malaria parasite. This research will reveal how malaria parasites perform extremely rapid replication of their DNA. Malaria is a major health burden in tropical regions, but our understanding of the parasite that causes this disease is limited. The malaria parasite lifecycle requires three stages of rapid replication, and we have recently identified new components of the parasite’s replication machinery that are likely responsible for this unique process. We will use new molecular and proteomics technologies, and integrate these with AI to reveal how proteins interact to facilitate rapid replication. Our findings will underpin future research aimed at developing new interventions for malaria and related infections in wildlife, livestock and humans.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Darren Creek