Developing chemical probes for effector triggered immunity in plants. Nucleotides play important roles in activation of plant immune responses to prevent pathogen infection and are therefore potential

Description

Developing chemical probes for effector triggered immunity in plants. Nucleotides play important roles in activation of plant immune responses to prevent pathogen infection and are therefore potential targets for development of crop protecting agents. This project aims to use chemical and structural biology approaches to develop stable and cell-permeable small molecules that can be used as chemical probes to study plant immunity. The expected outcomes include fundamental new knowledge on molecular mechanisms of plant immunity, and a synthetic toolbox that can modulate the plant immune system and be used for developing new strategies to protect crops from disease and invasive plants. This should provide significant benefits to agriculture and global food security.. Scheme: Discovery Projects. Field: 3404 - Medicinal and Biomolecular Chemistry. Lead: A/Prof Thomas Ve