Unravelling Molecular Mechanisms of SSA DNA Homologous Recombination. The repair of double-stranded DNA breaks is critical to the survival of all living organisms. One key process performing DNA repai

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Unravelling Molecular Mechanisms of SSA DNA Homologous Recombination. The repair of double-stranded DNA breaks is critical to the survival of all living organisms. One key process performing DNA repair is Single-Strand Annealing (SSA), which is a homologous DNA recombination pathway found in all life forms from viruses to humans. Despite its fundamental importance, the detailed molecular mechanisms of SSA and the structures of the protein complexes involved remain poorly understood. Our project aims to fill this critical gap by investigating the structural and functional mechanisms of the protein complexes carrying out SSA. Our project has far-reaching implications from enhancing the precision and efficiency of gene editing technologies to development of future anti-cancer and anti-bacterial therapies.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: A/Prof Gokhan Tolun