Molecular mechanism of the PRC-dependent RNA degradation by the rixosome. Polycomb repressive complexes (PRCs) and the rixosome are evolutionarily conserved enzymes that are required for silencing the

Description

Molecular mechanism of the PRC-dependent RNA degradation by the rixosome. Polycomb repressive complexes (PRCs) and the rixosome are evolutionarily conserved enzymes that are required for silencing the developmental genes of multicellular organisms. This project aims to investigate how these key regulators maintain gene repression using cutting-edge approaches ranging from biochemistry, structural biology, cell biology to genomics. The expected outcomes include generating new knowledge in gene regulation, strengthening the research capabilities of Australia in fundamental biology, and training the next generation of scientists. . Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Dr Qi Zhang