Leveraging electron microscopy to study receptor structure and function. This project aims to address key knowledge gaps regarding the molecular mechanisms of peptide hormone receptor function, using

Description

Leveraging electron microscopy to study receptor structure and function. This project aims to address key knowledge gaps regarding the molecular mechanisms of peptide hormone receptor function, using the parathyroid hormone receptor as a model system. This project expects to use an interdisciplinary approach, focused on cutting-edge microscopy techniques, to generate new insights. Expected outcomes of this project include a three-dimensional, step-by-step view of the receptor’s activation and deactivation process at high resolution, as well as optimised sample preparation methods for microscopy. This should provide significant benefits by greatly enhancing our understanding of this physiologically important receptor and potentially improving numerous future structural studies on similar receptors. . Scheme: Discovery Early Career Researcher Award. Field: 3101 - Biochemistry and Cell Biology. Lead: Dr Brian Cary