Identification and characterization of cellular derived immunogenic RNA. Cellular RNAs traverse the cytoplasm during their lifecycle and must be distinguishable from pathogenic RNA (e.g. virus) by the

Description

Identification and characterization of cellular derived immunogenic RNA. Cellular RNAs traverse the cytoplasm during their lifecycle and must be distinguishable from pathogenic RNA (e.g. virus) by the innate immune sensing system. A-to-I RNA editing of cellular RNA by ADAR1 is a critical mechanism in establishing and maintaining self-tolerance to cellular double-stranded RNA (dsRNA). However, despite a detailed understanding of the pathway mediating sensing and response to unedited cellular dsRNA, we lack definitive experimental evidence of the identity of the immunogenic dsRNA. This project directly addresses this by bringing together world leading fundamental knowledge and tools to define and experimentally validate the identity, features and characteristics of immunogenic cellular dsRNA.. Scheme: Discovery Projects. Field: 3102 - Bioinformatics and Computational Biology. Lead: Prof Carl Walkley