A new mechanism of bacterial membrane defence against environmental stress. Bacterial membranes serve as a critical barrier against external stress and often undergo changes to adapt. This project foc

Description

A new mechanism of bacterial membrane defence against environmental stress. Bacterial membranes serve as a critical barrier against external stress and often undergo changes to adapt. This project focuses on investigating a novel adaptive mechanism related to the production of lipoamino acids, a unique class of amino acid-containing lipids. Using systems biology and computational and biophysical tools, this project aims to elucidate the biogenesis of lipoamino acids and their impact on bacterial membrane stability, as well as their interactions with membrane-targeting compounds. By uncovering these mechanisms, this research will greatly enhance our understanding of bacterial adaption to environmental stress and may inform the future design of new antibacterial approaches specifically targeting bacterial membranes.. Scheme: Discovery Projects. Field: 3107 - Microbiology. Lead: Dr Meiling Han