Unlocking the mechanobiological events in oxygen unloading by erythrocytes. This project aims to use state-of-the-art technologies to reveal the process of oxygen release from red blood cells during m

Description

Unlocking the mechanobiological events in oxygen unloading by erythrocytes. This project aims to use state-of-the-art technologies to reveal the process of oxygen release from red blood cells during mechanical force exposure. This project expects to generate new knowledge on a vital biological process originally described using static models of cell-free haemoglobin that do not reflect the diffusive barriers to gas exchange or the mechanical dynamics of the in vivo environment. Expected outcomes include identifying molecular targets responsible for, and equations to accurately describe, the relation between mechanical stress and oxygen transfer. Benefits will include knowledge to improve models of biological dynamics and economic opportunities due to industry applications related to oxygen supply-demand management.. Scheme: Discovery Projects. Field: 4003 - Biomedical Engineering. Lead: Prof Michael Simmonds