Humanizing facultative heterochromatin in the yeast. In all multicellular organisms, cell type-specific genes are maintained repressed, unless their product is needed. The robust gene repression syste

Description

Humanizing facultative heterochromatin in the yeast. In all multicellular organisms, cell type-specific genes are maintained repressed, unless their product is needed. The robust gene repression system of multicellular organisms has been completely or partially lost in unicellular organisms. Yeast is a unicellular organism commonly used for fundamental research and biotechnology. This project aims to develop yeast strains that carry similar gene repression machinery as in multicellular organisms. By doing so, the project will allow gaining new knowledge into the way genes are turned off and maintained in a repressed state within cells during countless cell divisions. By generating methods for robust gene control in yeast, this project will also open paths for new biotechnology applications.. Scheme: Discovery Projects. Field: 3105 - Genetics. Lead: Prof Chen Davidovich