Unveiling the order of the gamma delta T cell immune synapse. B cells, ab T cells and gd T cells have co-evolved for 500 million years to fulfil unique roles. gd T cells have central roles in vertebr

Description

Unveiling the order of the gamma delta T cell immune synapse. B cells, ab T cells and gd T cells have co-evolved for 500 million years to fulfil unique roles. gd T cells have central roles in vertebrate development and immune defence. Poor understanding of gd T cell activation means these cells remain enigmatic and an immune research frontier. I will use cutting-edge cryo-electron and lattice-light sheet microscopy to answer this. Expected outcomes include molecular clarity of gd T cell triggers. Detail of gd T cell signalling cascades in concert with in situ studies will define how this immune cell lineage is activated. These discoveries will inform future immune and health research. This work will yield influential publications, foster international collaborations and advanced microscopy training.. Scheme: ARC Future Fellowships. Field: 3101 - Biochemistry and Cell Biology. Lead: Dr Benjamin Gully