The photochemical tool to probe peptide assembly across water and gas phase. The precise assembly of peptides into defined architectures is paramount for protein functionality, with any errors in this

Description

The photochemical tool to probe peptide assembly across water and gas phase. The precise assembly of peptides into defined architectures is paramount for protein functionality, with any errors in this assembly leading to severe diseases. Mass spectrometry, a leading tool for studying protein structures, operates in the gas phase. Tools that close the gap between peptide assemblies in their native state in water and in the gas phase are scarce. This project develops a conceptually unprecedented approach to study the assembly of peptides in both: water and gas phase. The CIs have recently shown that [2+2] photocycloadditions, key reactions of chemical synthesis, can be manipulated by peptide assembly. Exploiting this assembly sensitivity, photoreactions will be turned from a synthetic into a missing analytical tool.. Scheme: Discovery Projects. Field: 3404 - Medicinal and Biomolecular Chemistry. Lead: A/Prof Hendrik Frisch