Metabolic control of genome integrity - Insight into mechanisms. This project investigates how caloric restriction enhances organism fitness by improving DNA repair through the Target of Rapamycin (TO

Description

Metabolic control of genome integrity - Insight into mechanisms. This project investigates how caloric restriction enhances organism fitness by improving DNA repair through the Target of Rapamycin (TOR) pathway, a key nutrient and energy sensor in all eukaryotes. Preliminary research has revealed a novel energy-dependent mechanism by which the TOR pathway boosts DNA repair. This interdisciplinary project will use innovative methods to provide new insights into the effects of caloric restriction on DNA repair. Expected outcomes; include fundamental insights into the energy regulation of genome integrity to enhance organism fitness, new knowledge benefiting both basic and applied biology across all eukaryotes, potential future interventions in longevity and cancer research; fostering global collaborations.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Janni Petersen