New approaches to define protein function during malaria host cell entry. Apicomplexan parasites of humans and livestock, including malaria, survive by infecting and reproducing in host-cells. To enab

Description

New approaches to define protein function during malaria host cell entry. Apicomplexan parasites of humans and livestock, including malaria, survive by infecting and reproducing in host-cells. To enable host-cell entry, these parasites evolved sets of unique and shared proteins whose functions remain unknown. Using a multi-disciplinary approach, this project will define cross-species protein function of malaria proteins required for early and late stages of host-cell entry. Leveraging a substantial international network of research partners, outcomes of benefit to Australia include establishing a lead role in understanding the protein network driving different stages of malaria host-cell entry, characterisation of potential therapeutic targets and advancing imaging techniques applicable to other cellular systems.. Scheme: ARC Future Fellowships. Field: 3207 - Medical Microbiology. Lead: A/Prof Danny Wilson