Mapping the structure-function relationship of DNA origami in cells. DNA origami enables the precise design and creation of nanoparticles of any size and shape with unprecedented control. However, the

Description

Mapping the structure-function relationship of DNA origami in cells. DNA origami enables the precise design and creation of nanoparticles of any size and shape with unprecedented control. However, there is limited fundamental knowledge regarding the interactions between DNA origami nanotechnology and the intracellular environment. The proposed project will address this significant knowledge gap and dissect the structure-function relationship between DNA origami nanotechnology and the intracellular environment. The effect that material properties, such as size, shape and sequence, have on the stability, and fate of DNA origami objects in cells, will be elucidated. This multidisciplinary work will advance knowledge in bionanotechnology and cell biology, for engineering functional nanomaterials. . Scheme: Discovery Early Career Researcher Award. Field: 3106 - Industrial Biotechnology. Lead: Dr Jessica Kretzmann