Grants & Opportunities

Transforming Australian bio-based industries through multiscale modelling. Agricultural and forestry biomass can be converted into feedstocks for production of biofuels and biomaterials via synthetic biology. A key challenge is the complex biomass microstructure renders it highly resistant to conversion, and pretreatment is crucial for enhancing process efficiency. Micro-CT imaging will enable particle characterisation and identification of changes in the fibre composition during pretreatment. This information will be used to create a virtual biomass particle model for an in silico investigation to inform optimal process design. The framework will transform the way biomass is processed, contributing to the growth of the Australian bio-manufacturing industry by making it more productive, profitable and sustainable.. Scheme: Discovery Projects. Field: 4903 - Numerical and Computational Mathematics. Lead: Em/Prof Ian Turner

Click chemistry to reveal how neurons and glia shape perineuronal nets . The extracellular matrix (ECM) and its perineuronal nets (which are net-like structures with holes wrapped around neurons) are largely underexplored, despite representing a remarkable 20% of the brain’s total volume and having been suggested to be involved in many brain functions. Interestingly, digestion of the ECM improves learning and memory, but deficits return once the ECM has reformed. However, how this ECM remodelling is organised at a cell-type level is not understood. Here we aim to close this knowledge gap, using cutting-edge technology including bioconjugation and ultrasound-mediated cargo delivery. Together, this project aims to contribute to a deeper understanding of this major brain compartment in neuronal function. . Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Jürgen Götz

Origin and evolution of animal-bacterial symbiosis. This project seeks to understand how interactions between animals and their microbial symbionts – the holobiont – evolved, and how they are influenced by the environment over an animal's life. Using a homegrown Australian model, a sea sponge from the Great Barrier Reef, and advanced multi-omic approaches (genomics plus cell biology), this project aims to uncover the mechanisms underlying the establishment and maintenance of the holobiont through development, and under changing ecological and environmental conditions. Because of the evolutionary position of sponges, outcomes of this project expect to reveal cardinal rules governing animal-microbe interactions that are fundamental to the health and conservation of most animals and ecosystems.. Scheme: Discovery Projects. Field: 3104 - Evolutionary Biology. Lead: Prof Sandie Degnan

Development of a novel best approximation theory with applications . The aim of this project is to develop an innovative best approximation theory for complex fractional boundary value problems with discontinuities and with no compactness, and then apply the theory to study two classes of complex partial differential equation boundary value problems with industrial applications. The work will lead to the development of a new theory and a suite of innovative analytical and computational methods for solving a wide range of nonlinear problems with singularities and non-local properties. The expected outcomes of the project will significantly advance our methods for the modelling and control of many industrial systems and processes. . Scheme: Discovery Projects. Field: 4901 - Applied Mathematics. Lead: Prof Yong Hong Wu

From mainstream to margins: The denormalisation of underage heavy drinking. This mixed-methods study aims to investigate changes in, and contemporary experiences of, heavy drinking for underage young people in Australia. The project expects to generate new knowledge on whether and how processes of ‘de-normalisation’ are shaping heavy drinking practices and experiences of social inclusion for underage young people. Expected outcomes of the project include the development of a contemporary theoretical model of underage drinking. This should provide significant benefits such as advancing understanding of the social and structural factors shaping heavy underage drinking practices. Findings can be used to inform policy directions aiming to holistically maximise health and social wellbeing for young people.. Scheme: Discovery Projects. Field: 4410 - Sociology. Lead: Dr Amy Pennay

Mapping & Harnessing Public Mistrust: Constitutional Values Survey 2023-27. Declining public trust is well recognised as a problem of democratic government, including in Australia. However solutions are more elusive, confounded by the reality that mistrust and distrust play not just negative, but positive roles in our existing political and constitutional traditions. This project aims to be the first to comprehensively map the positive values of mistrust in citizen political attitudes and experience, building on previous Constitutional Values Surveys (2008-21) to test new measures of the content of trust including a first-ever longitudinal study of changing trust over time. The results will inform concrete solutions to three key policy reform dilemmas, providing better answers for sustaining public trust overall. . Scheme: Discovery Projects. Field: 4408 - Political Science. Lead: Prof Alexander Brown

Evolution and mechanisms of interactions in biofilm communities. This project aims to study the long-term experimental evolution of a mixed species bacterial biofilm community. This project expects to gain understanding of the genetic and physiological basis of community evolution. Expected outcomes of this project will be an understanding of how synthetic communities evolve. This will significantly benefit the use of synthetic communities relevant to fields such as antibiotic design, biotechnology, bioremediation, and synthetic biology where evolution can be inhibited or exploited, respectively.. Scheme: Discovery Projects. Field: 3105 - Genetics. Lead: Prof Diane McDougald

Distributed Optimisation without Central Coordination. This project will develop the mathematical foundations for discovery and analysis of iterative methods for optimisation problems in distributed computing systems. Most methods in distributed optimisation were not designed for distributed computing, rather they were adapted for purpose post-hoc. By building on recent advances in monotone operator splitting, this project expects to develop a mathematical theory for decentralised optimisation algorithms specially designed for distributed systems. The framework is expected to produce a suite of algorithms, each customised to exploit a specific network configuration. The project will provide significant benefits in distributed machine learning applications such as federated learning.. Scheme: Discovery Projects. Field: 4901 - Applied Mathematics. Lead: A/Prof Matthew Tam

Homogenous Antibody-Metal Conjugates For Immuno-Mass Spectrometry Imaging. This project aims to use bespoke metal labels and high-resolution mass spectrometry imaging to address current shortcomings in approaches that visualise and measure proteins in cells and tissue. It expects to substantially increase the utility of immuno-mass spectrometry imaging technology to analyses that are refractory to current techniques and workflows. Expected outcomes include metal probes that facilitate the spatial quantification of multiple biomolecules on a single histological section, providing significant benefits to bioscience laboratories that require complex workflows to visualise and obtain quantitative data on the expression of biomolecules.. Scheme: Discovery Projects. Field: 3401 - Analytical Chemistry. Lead: A/Prof David Bishop

Probing new physics with atomic parity violation. This project aims to provide a new level of rigour in tests of the standard model of particle physics at low energies, and to reveal or more tightly constrain new particles or forces. This will involve the development of state-of-the-art atomic theory techniques and collaboration with world-leading experimental groups. The expected outcomes and benefits include a breakthrough in the precision of atomic theory calculations, new insights into nuclear magnetic structure, improved determination of fundamental particle physics parameters, stronger ties with the international experimental community, enhancing Australian leadership and expertise, and high-level training of the next generation of scientists.. Scheme: Discovery Projects. Field: 5102 - Atomic, Molecular and Optical Physics. Lead: A/Prof Jacinda Ginges

Dynamic Microcages for Cells: Advanced Tools to Interrogate Cell Mechanics. This project aims to develop a suite of movable micro/nanostructures with integrated mechanical and biological sensors, which will be interfaced with cells to investigate how those cells respond to their surrounding physical environment. Expected outcomes are new technologies in micro/nanofabrication, sensing, and advanced imaging, and deep understanding of the biological processes that control tissue formation and repair. These outcomes would impact how 3D microsystems are developed and applied, informing the design of advanced in-vitro cell culture systems. Significant benefits are expected in 3D nano-microengineering, and in generating new knowledge underpinning future advances in stem cell and tissue engineering technologies.. Scheme: Discovery Projects. Field: 4018 - Nanotechnology. Lead: Prof Nicolas Voelcker

Engineering Fungal Nonribosomal Peptide Synthetases for Novel Alkaloids. This project aims to use protein-domain shuffling aided by structural biology to decode and engineer a class of modular megaenzymes, called nonribosomal peptide synthetases (NRPSs), in fungi. These are responsible for the biosynthesis of peptide-derived bioactive molecules, such as the antibiotic penicillin and the immunosuppressant cyclosporin. Expected outcomes of this project include a fungal NRPS engineering platform for generating new molecules with desirable biological activities that can be readily scaled up for sustainable bioproduction. This will provide significant benefits to Australia through the development of cutting-edge biotechnologies as well as the discovery of new pharmaceuticals, veterinary products and agrichemicals.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: A/Prof Yit Heng Chooi

Responding to Sexual Harm: An Australian Historical Criminology Approach . Despite sustained interventions from the 1970s onwards, sexual harm is a problem of enormous magnitude within Australia. The project focuses on contemporary histories of reform, aiming to understand how social, political, legal and cultural contexts have shaped experiences and conceptualisations of sexual harm. This project expects to generate vital knowledge on the impacts of recent historical reforms on diverse communities, advance mixed methods and co-design approaches in historical criminology, and enhance Australia’s research capacity by training a new team of topic matter experts. By understanding the impacts of past reform, findings should provide significant benefits in informing future reforms and responses to sexual harm.. Scheme: Discovery Projects. Field: 4303 - Historical Studies. Lead: Prof Lisa Featherstone

Overcoming nonlinearity in short-reach optical communication. This project aims to investigate the equalization methods for nonlinear optical channels applicable to short-reach optical communications. This project expects to significantly improve the transmission capacity of the cost-effective directly detected transceivers. Expected outcomes of this project include advanced equalization techniques for nonlinear channels and associated signal processing algorithms. These advances will have the potential to provide an enabling technology for surging capacity demand from cloud computing and enhance Australia's standing as a leader in optical communications technology. . Scheme: Discovery Projects. Field: 4006 - Communications Engineering. Lead: Dr Jingge Zhu

Defining how signalling pathways cooperate to regulate organ size. Control of organ size is essential for organ function and organism viability, and varies greatly across the animal kingdom. This project aims to understand how three important signalling pathways co-ordinately regulate organ size during development and also limit aberrant growth. By applying genomics, genetics and bioinformatics techniques, this project aims to discover a core set of growth genes that are regulated by different signalling pathways and the mechanism by which transcription of these genes is repressed in order to eliminate faulty cells. Intended benefits are creation of jobs, new knowledge on fundamental principles of life and the stimulation of new research into organ size control.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Kieran Harvey

Labour Market and Health Dynamics of Australia's Front Line Workers. Australia’s front line workers are there in times of greatest need, but face significant health risks. These risks are expected to increase with the predicted growth in natural disasters, and these concerns have been heightened by the COVID-19 pandemic. This project will apply econometric methods to population-based administrative data to study (1) the determinants and patterns of recruitment and retention into these occupations, (2) how labour market and health outcomes are impacted by exposure to major disasters; and (3) the impact of the pandemic on labour market and health outcomes. The project will provide insights that can inform policies designed to protect the health of front line workers and meet future workforce demands.. Scheme: Discovery Projects. Field: 3801 - Applied Economics. Lead: A/Prof Sonja De New

Sex Differences in Trait Associations & Shapes: Analysis beyond Average. This project aims to identify and address current knowledge gaps in research on sex differences by employing different methodologies (bibliometrics, systematic mapping) and developing novel methods of meta-analysis. This project expects to generate a more holistic and complete view of sex differences than currently appreciated, by (meta-)analyzing the shapes of traits and associations between traits. Expected outcomes of the project include taking the field of sex differences to the next level, and creating new and powerful meta-analytic methods, opening new avenues for research synthesis. This should provide significant benefits by directing future research in related fields and inspiring new kinds of (meta-)analyses across disciplines.. Scheme: Discovery Projects. Field: 3104 - Evolutionary Biology. Lead: Dr Malgorzata Lagisz

Global integration of microbial community and climate data. Microbial communities in the environment control the cycling of carbon and nutrients on Earth, but climate models do not directly incorporate microbial inputs. This interdisciplinary project will link planetary-scale climate modelling data with novel large-scale microbial community analysis, using climate information to provide insight into the fantastic diversity of microbial processes on our planet. The interdisciplinary approach will inform the next generation of climate models and better predict our future climate’s feedbacks. Conversely, it will make progress on the grand challenge of understanding microbial community function by enabling microbial ecology to be treated as a data-intensive machine learning problem.. Scheme: Discovery Projects. Field: 3107 - Microbiology. Lead: A/Prof Benjamin Woodcroft

Regulation of lung immune-epithelial networks sensing environmental change. This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic substances. Understanding this molecular program of epithelial-immune cell-mediated sensing/repair will be essential to understand how tissue-repair processes can be driven in the lung, an organ critical for respiration and thus life.. Scheme: Discovery Projects. Field: 3204 - Immunology. Lead: Prof Gabrielle Belz

Extracting subtle hints for new phenomena at the Large Hadron Collider. This project aims to investigate the detailed nature of the Higgs theory which underpins the mass of elementary particles. The project aims to increase the understanding of particle interactions in the context of precise measurements of the properties of the Higgs boson that will come out of the experimental program at the large hadron collider. Expected outcomes include the development and application of methods to address existing gaps in the framework that confronts theory and experiment and to efficiently explore its high dimensionality. The benefits of conducting this research in Australia include the development of intellectual culture and the training of early-career researchers as flexible problem solvers in academia or beyond. . Scheme: Discovery Projects. Field: 5107 - Particle and High Energy Physics. Lead: Prof German Valencia

The first English speakers in their own words. This project aims to produce the first comprehensive study of the attitudes in the earliest English literature. The project expects to generate new knowledge about the first English speakers, what issues mattered most to them and how broad the range of attitudes was. Expected outcomes of this project include new approaches to studying the past, enhanced international collaborations and a public access to the project's data through an open access digital resource. This should provide significant benefits in terms of our understanding of the past and how it shapes attitudes in contemporary Australia. . Scheme: Discovery Projects. Field: 4705 - Literary Studies. Lead: A/Prof Erin Sebo

Efficient and secure data integrity auditing on cloud. Data auditing presents a promising way for verifying user data integrity on cloud, i.e., whether user privacy sensitive data such as identity information on cloud is modified or lost. Current auditing approaches lack sufficient efficiency and security. This results in that they cannot provide timely warning and precaution on potential data loss threats. This project aims to systematically investigate this significant challenge and expects to establish innovative research and solutions for enabling efficient and secure data integrity auditing on cloud. The project outcomes will help to safeguard Australian community in fast-growing cyber world, and benefit to fast-growing user privacy sensitive data hosting and applications on cloud.. Scheme: Discovery Projects. Field: 4604 - Cybersecurity and Privacy. Lead: Prof Jinjun Chen

Genome evolution & adaptation of the multinuclear wheat stripe rust fungus. Animals and plants package their genomes into a single nucleus within each cell. In contrast, millions of fungal species accommodate multiple nuclei containing individual haploid genomes. It is currently unknown what the evolutionary implications are for this unusual genome division into multiple nuclei. Here we explore the evolutionary consequences of genome division into multiple nuclei for the first time by applying cutting edge genome biology tools and algorithms. The economically significant study system is the devastating wheat stripe rust fungus. This pathogen costs Australian farmers over $100 million a year. New understanding is expected to lead to better disease management, reduced fungicide applications, and increased yields.. Scheme: Discovery Projects. Field: 3102 - Bioinformatics and Computational Biology. Lead: Prof Benjamin Schwessinger

Ultra-Fast and Secure Terahertz Communications for 6G Wireless Systems. This project aims to develop new theories and signal processing solutions for the cutting-edge technology of terahertz communications to enable the revolutionary sixth-generation wireless systems, by exploring and optimising the inherent benefits of the terahertz band. Anticipated outcomes are new analytical tools and practical guidelines for designing ultra-fast and secure wireless transmission at an unprecedented speed up to terabits per second (Tbps). This enables various emerging applications, such as holographic telepresence, Tbps WiFi and Tbps wireless data centres, to drive transformation in the telecommunications sector, boost industry productivity and support our intelligent information society in the 2030s.. Scheme: Discovery Projects. Field: 4006 - Communications Engineering. Lead: Prof Nan Yang

Archiving Social Movements & Building Historical Literacy for a Digital Age. This project aims to investigate how the history of social movements has been collected, catalogued and curated by archives and museums. It is significant because it will make these histories available to form an equitable and inclusive civic culture. An expected outcome is an interdisciplinary approach producing new knowledge about citizens’ roles in shaping private and public collections, and about the use of these collections to shape memory and generate wider historical literacy. Benefits include providing insight into inclusive physical and digital collecting practices, which enables the project to address UNESCO’s goal of achieving greater access to decision-making about culture, heritage and the formation of social identities.. Scheme: Discovery Projects. Field: 4302 - Heritage, Archive and Museum Studies. Lead: Prof Sharon Crozier-De Rosa