Grants & Opportunities

Some like it hot: the genetics of rapid adaptation to climate change. This project investigates the genetics of rapid evolutionary adaptation by utilising genomes sampled over unparalleled temporal and spatial scales in a highly invasive and agriculturally significant weed. This project expects to generate new knowledge about the genetic mechanisms that facilitate adaptation to climate change by developing new theory and genomic predictions, and then testing them under realistic field conditions. Expected outcomes include a deeper understanding of the genetic basis of adaptation, and a powerful framework to predict the evolutionary consequences of climate change. This should provide significant benefits, including improved capacity to anticipate the effects of climate change on noxious and threatened species.. Scheme: Discovery Projects. Field: 3104 - Evolutionary Biology. Lead: A/Prof Kathryn Hodgins

The Ethics of Voluntary Assisted Dying: Promoting Constructive Debate. This project aims to analyze core concepts that play key roles in emerging debates about the ethics of Voluntary Assisted Dying (VAD) in Australia. The project expects to make constructive contributions to these debates, promoting respectful dialogue and reducing polarization. Expected outcomes include a new model for managing VAD in Australia which is ethically appropriate and consistent with community values. This model will also benefit other countries where the ethics of VAD is under consideration. The project will promote the dignity and autonomy of all and ensure that issues about the conscientious refusal of healthcare professionals to participate in the provision of VAD are handled in an ethically appropriate and effective manner.. Scheme: Discovery Projects. Field: 5001 - Applied Ethics. Lead: Prof Stephen Clarke

Nuclear RNA surveillance and its connection to splicing quality control. Due to the error-prone nature of RNA splicing, elaborate quality control processes ensure that only correctly spliced transcripts can leave the nucleus. It has long been known that incorrectly spliced mRNA transcripts are degraded by the nuclear RNA surveillance machinery, but how the RNA quality control machinery is connected to nuclear RNA surveillance is not known. This proposal aims to uncover the connection between these two important processes and will fill a significant gap in our understanding of how splicing quality control and nuclear RNA surveillance work. The project will also identify sequence features that trigger abortive splicing reactions and will thus help to improve the design of synthetic mRNAs.. Scheme: Discovery Projects. Field: 3105 - Genetics. Lead: A/Prof Tamas Fischer

Towards a cognitive process model of how attention and choice interact. Before making any decision, we must gather information on what options are available. This process may influence the choices we make: if we do not notice an option, we will not choose it even if it would have been valuable. This project aims to examine how prior experience can produce attentional biases that influence decisions, and will develop a new computational model of this interaction of attention and choice as an outcome. This new knowledge will enhance the world-class status of Australian cognitive psychology. Moreover, it should provide significant benefits through improving our ability to predict and shape behaviour, and shedding light on the role of biases in healthy cognition and in the context of compulsive behaviours.. Scheme: Discovery Projects. Field: 5204 - Cognitive and Computational Psychology. Lead: Prof Mike Le Pelley

Networks: New links between spectrum, dynamics, rewirings and applications. Modern network science has transformed the study of complex systems and led to innovations in many disciplines. This project intends to develop breakthrough theories for control of complex networked system behaviour via interventions of the link-rewiring type. New approaches will be developed for non-random, assortative and/or structured networks, which are poorly understood and difficult to deal with, despite being the real-world norm and despite their impact. The results will give new insights into epidemic outbreaks and their impact on vulnerable groups (e.g., elderly and indigenous), and provides methods to enforce resilience of infrastructure networks such as power grids, thereby providing significant economic and societal benefits. . Scheme: Discovery Projects. Field: 4901 - Applied Mathematics. Lead: Prof Lewi Stone

Dissecting bacterial signal transduction. Bacteria have feelings. They sense and respond to changes using proteins called two-component signalling systems (TCSS). These comprise a sensor which activates a DNA binding protein in response to specific cues (signals). Using state-of-the-art genetic techniques and a synthetic biology approach, this research aims to reveal for the first time how these complex bacterial TCSS networks interact. The outcomes will be a fundamental, new understanding of how bacteria sense and respond to environmental signals; a deep dive into how bacteria feel. This knowledge will be the basis for innovative approaches to harness bacteria in biotech such as vaccine production, biofuels, or clever therapeutic interventions to stop bacterial infections.. Scheme: Discovery Projects. Field: 3107 - Microbiology. Lead: Prof Timothy Stinear

How Large Earthquakes Change Our Dynamically Deforming Planet. The project aims to understand the multiscale dynamics of interacting faults on a global scale using novel computer simulations with unprecedented spatial and temporal resolution. The focus of the research is to investigate the two-way coupling that exists between cycles of great earthquakes on plate boundaries, the global stress field, deformation within the crust, and changes to the Earth's dynamic topography. This is an important, foundational question in the emerging field of decadal scale global geodynamics. The tools are intended to improve reference models used to study sea-level changes in response to global ice loss. They support better climate models and improved forward planning tools for at-risk coastal communities.. Scheme: Discovery Projects. Field: 3706 - Geophysics. Lead: Prof Louis Moresi

Control of crop-microbe symbiosis by new plant hormones. This project aims to discover how plants use hormone-like chemicals, called butenolides, to control symbiotic relationships with soil fungi. It will use multidisciplinary and collaborative techniques to establish how butenolide metabolism affects the diversity of fungal colonisation. Expected outcomes of this project include a deeper understanding of how plants regulate the competency of roots to host symbiotic fungi, and how this affects plant growth. As such, it will generate knowledge of how cereals such as barley could be modified to improve their nutrient use efficiency. Benefits of this project include the potential to reduce fertiliser inputs, thereby improving the competitiveness and environmental impact of Australian agriculture.. Scheme: Discovery Projects. Field: 3108 - Plant Biology. Lead: A/Prof Mark Waters

Fluid chemistry and critical mineral enrichment in salty metamorphic belts. Several geological regions in Australia are worth billions of dollars to our economy in their contained copper-goldcobalt and uranium-rare earth element mineral deposits. These regions will continue to be important to Australia as the world transitions to a renewable energy economy because they can provide some of the most critical metals needed for that transition: Cu, Co, rare earth elements. This project aims to provide a fundamental quatitative understanding of the geological processes that form these deposits. We will conduct experiments to generate quantitative models of the metamorphic and structural processes that control the liberation and migration of highly saline fluids, which are ideal for transporting a large range of metals.. Scheme: Discovery Projects. Field: 3705 - Geology. Lead: Prof Andrew Tomkins

“Janus” Transition Metal Dichalcogenides: Quest for Novel Properties . Novel two-dimensional nanomaterials – so called “Janus” transition metal dichalcogenides (TMDs) - are featured by breaking out-of-plane structural symmetry that enables prolongated exciton lifetime, strong spin-orbit coupling, large vertical piezoelectric polarization, and exceptional electromechanical properties. We plan to develop reliable and efficient synthetic routes for various "Janus" TMDs and their heterostructures, to investigate their physical properties, and find the ways of property tailoring. Deep understanding of structure-property relationships uncovered for these materials will pave the way for transferring discovered new features into cutting-edge technologies in electromechanical, optoelectronic, and catalytic fields.. Scheme: Discovery Projects. Field: 3403 - Macromolecular and Materials Chemistry. Lead: Prof Dmitri Golberg

Developing vitrimers: next generation reusable plastics. This project aims to develop a new class of advanced multifunctional polymer materials with the potential to underpin significant breakthrough capabilities for soft materials in general. The proposed work will relocate biological catalysts from their native, wet environment to solid organic engineering bio-sourced resins. Suitably selected enzymes will allow creation of polymer-based products that can be fully recyclable, with built-in properties such as self-healing, shape morphing, which are mechanically tunable, and have the ability to be reprocessed/recycled multiple times. This research will initiate a disruptive change in the application of biocatalysts for bio-based polymers.. Scheme: Discovery Projects. Field: 3403 - Macromolecular and Materials Chemistry. Lead: A/Prof Matthieu Gresil

Consumer and Community Involvement Process Implementation Model . The project aims to examine the barriers and enablers to Consumer and Community Involvement. We will generate new knowledge via innovative methods from narrative medicine and economic and marketing studies including establishing the first Community of Practice for consumers and stakeholders in dementia research as the example. The outcomes include the creation of a process implementation model for Consumer and Community Involvement to inform policies and guidelines for research systems and funding. This process model will propel research forward and generate opportunities to maximise the health and social benefits of research, including significant translation of research into practice. . Scheme: Discovery Projects. Field: 4407 - Policy and Administration. Lead: A/Prof Darshini Ayton

Novel tractography-guided MRI methods for studying healthy brain ageing. Advances in imaging, and particularly Magnetic Resonance Imaging, have opened a new era in the study of the brain enabling a myriad of neuroscience discoveries. This project aims to develop new analysis methods to study and understand the variability in the human brain during ageing, exploiting the wealth of information contained in the so-called tractogram, a mapping of the brain’s wiring. This project expects to develop innovative imaging biomarkers to characterise the brain changes in the course of healthy brain ageing. Expected outcomes include novel imaging tools for neuroscience, which should allow us to map trajectories of normative healthy brain ageing and use them to identify lifestyle factors that impact these trajectories.. Scheme: Discovery Projects. Field: 4003 - Biomedical Engineering. Lead: Prof Fernando Calamante

Replicating the cartilage micromechanical environment. Through a novel, image-guided mechanical evaluation of cell- and tissue-level remodelling, this project aims to unlock new insights into the complex mechanical microenvironment of cartilage and directly influence new strategies in tissue engineering. The research will reveal contributions of cells and extracellular matrix components to mechanical integrity over time. It will build a world-first strain map of the cartilage microenvironment and quantification of dynamic structural remodelling that occurs, providing key targets to improve tissue engineering strategies. The project will also drive innovation in micromechanical testing technology, deliver functional solutions in mechanobiology and advance materials for biological integration.. Scheme: Discovery Projects. Field: 4003 - Biomedical Engineering. Lead: Prof Kathryn Stok

Sex-specific epigenetic atlas across lifespan . This project aims to uncover sex-specific molecular marks that either predict or mediate healthy ageing across multiple tissues in humans. This project expects to generate new knowledge of cellular heterogeneity and epigenetic control of phenotype and healthy ageing. Further, we anticipate to uncover age-associated changes that differ between males and females, an area of chronic research under representation. These outcomes will lead to a comprehensive understanding of fundamental biological processes across lifespan, and our development of an open access atlas will underpin evidence-based personalised health strategies to keep Australians healthier for longer. . Scheme: Discovery Projects. Field: 3105 - Genetics. Lead: Prof Nir Eynon

Defining a new family of sodium channel accessory proteins. Voltage-gated sodium channels are key proteins that function as multi-subunit complexes to regulate neuronal excitability. The project aims to investigate the structure and function of a novel family of accessory subunits by utilizing a class of toxins, derived from the giant Australian stinging tree, that directly binds to these proteins to modulate sodium channel function. The project aims to generate significant new knowledge on the function of sodium channels as multi-protein complexes. Expected outcomes of this project include development of novel channel-modulating molecules that may have applications as neuroscience tools to address fundamental questions about ion channel function and biology.. Scheme: Discovery Projects. Field: 3404 - Medicinal and Biomolecular Chemistry. Lead: Prof Irina Vetter

Moral Injury and the Ethics of Military Conditioning . Military personnel undergo extensive conditioning in the name of combat effectiveness and resilience. The aim of this project is to determine whether any of the intended effects of this conditioning constitute "moral injuries", and to describe the ethical and policy implications if so. This will deepen our understanding of the ethics of military recruitment, training, and socialisation. The expected outcomes include a statement of the obligations owed to professional soldiers on account of the potential for moral injury in preparing them for deployment. This will enhance Australia’s reputation for being ethically proactive and for taking a holistic approach to the welfare of its military servicemen and women.. Scheme: Discovery Projects. Field: 5003 - Philosophy. Lead: A/Prof Ned Dobos

Economic analysis of child maltreatment and child protection. This project aims to investigate the economic causes and consequences of child maltreatment. It expects to generate new knowledge by applying microeconometric methods to large Australian administrative databases that track children’s health, education and welfare receipt over time. The expected outcomes of this project include an expanded knowledge base on how economic shocks affect maltreatment, the economic consequences of placing children in out-of-home care, and the value of economic policies for reducing the intergenerational transmission of maltreatment. This should provide significant benefits, such as providing practical evidence to policy makers and service providers that help prevent child maltreatment and reduce its harms.. Scheme: Discovery Projects. Field: 3801 - Applied Economics. Lead: A/Prof Nicole Black

Informing intervention responses to violent offenders through data linkage. The project aims to capitalise on new data access capacity to improve knowledge on violent offender pathways and criminogenic needs, such as acquired brain injury, to reduce offending and re-offending. Violence is a major social and health issue nationally and internationally. While there has been substantial investment in treatment/prevention campaigns, rates of violence remain high. Using diverse linked administrative data, we will identify key risk factors and times in trajectories, as well as effective treatment/justice responses. Expected benefits include evidence-based recommendations and engagement with policymakers targeting recidivism, offender screening, treatment, and coordinated violence prevention policy and practice.. Scheme: Discovery Projects. Field: 5205 - Social and Personality Psychology. Lead: Prof Peter Miller

Beyond Query: Exploratory Subgraph Discovery and Search System. Exploring co-working user groups in dynamic network data is a vital challenge in many applications, for example, in online education. This project aims to discover new relationships of users and compute their co-working performance in continuous time periods. The outcomes of the project are to design effective subgraph exploratory models, three novel types of subgraph search solutions, and devise a friendly exploratory subgraph search system for supporting the real-time network data analytics. The success of the project will make a significant contribution to the scientific foundation of graph data mining and its applications in data engineering domains, as well as benefiting co-working performance of people in Australian labor markets.. Scheme: Discovery Projects. Field: 4605 - Data Management and Data Science. Lead: Prof Jianxin Li

Innovative Electrohydrodynamic Atomisation for Improved Nasal Drug Delivery. Inhalation offers high and rapid drug absorption into the bloodstream. This project aims to establish key technologies for a revolutionary system in inhaled nanomedicine delivery. The study will investigate the underlying physics of nanoparticles to create a world-first electrostatic nebuliser, enabling the more effective drug delivery. This technique is expected to overcome the current limitations by providing better control over the size and charge of delivered drugs. The outcomes of this project will benefit pharmaceutical companies in developing products with more efficient nasal delivery of advanced drugs, vaccines, and nanocariers, make it easier for doctors to prescribe, and benefit patients with more accurate dosages.. Scheme: Discovery Projects. Field: 4017 - Mechanical Engineering. Lead: A/Prof Van Dau

Temporal Graph Mining for Anomaly Detection. This project aims to develop new technologies to detect anomalous patterns from dynamic networked data. Anomalies in networked data are commonly seen but are often hidden within the complex interconnections of large-scale, heterogeneous, and dynamic data, rendering existing detection methods ineffective. This project expects to design novel temporal graph mining techniques to compress large-scale networks, unify heterogeneous information, and enable label-efficient anomaly detection. The performance will be assessed in social and business networks, with significant benefits to governments and businesses in many critical applications, including cyberbullying detection, malicious account detection, and cyber-attack detection.. Scheme: Discovery Projects. Field: 4605 - Data Management and Data Science. Lead: Prof Shirui Pan

Human models for accelerated robot learning and human-robot interaction. This project aims to develop novel approaches to teach robots to proficiently interact with humans in a safe and low-cost manner. To achieve this aim, this project will develop novel models from which various human behaviours can be generated and used to train human-robot interaction policies in simulation. Expected outcomes of this project include new computational models of human behaviour built using cognitive science theories and limited data and new training schemes for robot learning in simulation. By training robots in simulation with accurate human models, this research will enable fast and safe robot training to support the deployment and adoption of robots in human contexts such as healthcare facilities, homes, and workplaces.. Scheme: Discovery Projects. Field: 4602 - Artificial Intelligence. Lead: Prof Dana Kulic

Australian Journalism, Trauma and Community. This project aims to investigate the professional and personal costs of reporting on trauma for Australian journalists and the communities they engage with, by undertaking a groundbreaking historical study of journalists’ exposure to trauma over the past century. It seeks to generate new knowledge by transforming our understanding of the relationship between journalism and trauma and the wider implications for the profession and the public. Expected outcomes of this project include scholarly, education and public resources which will inform and broaden ongoing debates about Australian journalism. This will provide significant benefits for journalists and the public, creating urgent awareness and better support and training initiatives. . Scheme: Discovery Projects. Field: 4303 - Historical Studies. Lead: A/Prof Fay Anderson

Molecular mechanism of the PRC-dependent RNA degradation by the rixosome. Polycomb repressive complexes (PRCs) and the rixosome are evolutionarily conserved enzymes that are required for silencing the developmental genes of multicellular organisms. This project aims to investigate how these key regulators maintain gene repression using cutting-edge approaches ranging from biochemistry, structural biology, cell biology to genomics. The expected outcomes include generating new knowledge in gene regulation, strengthening the research capabilities of Australia in fundamental biology, and training the next generation of scientists. . Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Dr Qi Zhang